Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane.

نویسندگان

  • Y Zhang
  • S Wu
  • E I Eger
  • J M Sonner
چکیده

UNLABELLED Inhaled anesthetics produce immobility (a cardinal aspect of general anesthesia) by an action on the spinal cord, possibly by potentiating the responses of gamma-amino-n-butyric acid (GABA(A)) and glycine receptors to GABA and glycine. In this study, we antagonized GABA(A) and glycine responses by intrathecal administration of picrotoxin (a noncompetitive GABA(A) antagonist), strychnine (a competitive glycine antagonist), or combinations of these drugs. We measured the capacity of antagonist infusion to increase isoflurane MAC (the minimum alveolar concentration of anesthetic that prevents movement in response to noxious stimuli in 50% of subjects). We found that these potent GABA(A) and glycine receptor antagonists had a ceiling effect, either alone or in combination increasing the MAC of isoflurane by at most 47%. IMPLICATIONS gamma-amino-n-butyric acid and glycine receptors may in part be responsible for the immobilizing action of isoflurane. They are not, however, the only receptors that contribute to isoflurane-induced immobility (i.e., that determine the MAC of isoflurane).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

نقش گیرنده‌های محیطی گلیسین در اخذ غذای وابسته به گیرنده‌های کانابینوئیدی

Background & Aim: Peripheral cannabinoid and glycine receptors are involved in food intake regulation. This study was conducted to investigate the possible interaction between these two receptors in regulating food intake. Methods: This is an experimental study which was conducted on forty male Wistar rats. In the first phase of the experiment, the rats simultaneously received intraperitonea...

متن کامل

E ffects of chronic ethanol consumption on rat GABA and strychnine - A sensitive glycine receptors expressed by lateral / basolateral amygdala neurons 1 * Brian

It is well known that the anxiolytic potential of ethanol is maintained during chronic exposure. We have confirmed this using a light–dark box paradigm following chronic ethanol ingestion via a liquid diet. However, cessation from chronic ethanol exposure is known to cause severe withdrawal anxiety. These opposing effects on anxiety likely result from neuro-adaptations of neurotransmitter syste...

متن کامل

E ffects of chronic ethanol consumption on rat GABA and strychnine-

It is well known that the anxiolytic potential of ethanol is maintained during chronic exposure. We have confirmed this using a light–dark box paradigm following chronic ethanol ingestion via a liquid diet. However, cessation from chronic ethanol exposure is known to cause severe withdrawal anxiety. These opposing effects on anxiety likely result from neuro-adaptations of neurotransmitter syste...

متن کامل

Characterization of strychnine-sensitive glycine receptors in acutely isolated adult rat basolateral amygdala neurons.

Large concentrations of the beta-amino acid, taurine, can be found in many forebrain areas such as the basolateral amygdala, a portion of the limbic forebrain intimately associated with the regulation of fear/anxiety-like behaviors. In addition to its cytoprotective and osmoregulatory roles, taurine may also serve as an agonist at GABA(A)- and strychnine-sensitive glycine receptors. In this lat...

متن کامل

Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics.

The present study was designed to investigate the role of strychnine-sensitive glycine receptors in hypnosis and analgesia induced by emulsified volatile anesthetics. After having established the mice model of hypnosis and analgesia by intraperitoneally injecting (i.p.) appropriate doses of ether, enflurane, isoflurane or sevoflurane, we intracerebroventricularly (i.c.v.) or intrathecally (i.t....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Anesthesia and analgesia

دوره 92 1  شماره 

صفحات  -

تاریخ انتشار 2001